Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells
نویسندگان
چکیده
منابع مشابه
Molecular Dynamics Simulation of Water Transportation through Aquaporin-4 in Rat Brain Cells
This paper investigates the mechanism of water transportation through aquaporin-4(AQP4) of ratbrain cells by means of molecular dynamics simulation with CHARMM software. The AQP4 wasembedded into a bilayer made of Dimystroilphosphatylcholine (DMPC). The results illustrate thatwater molecules move through AQP4's channel with change of orientation of oxygen of eachwater molecule.
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Membrane water transport is critically involved in brain volume homeostasis and in the pathogenesis of brain edema. The cDNA encoding aquaporin-4 (AQP4) water channel protein was recently isolated from rat brain. We used immunocytochemistry and high-resolution immunogold electron microscopy to identify the cells and membrane domains that mediate water flux through AQP4. The AQP4 protein is abun...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2008
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2007.08.007